Phosphocalcium balance
Bmd now offers an ELISA range making it possible to diagnose part of the phosphocalcium balance, Vitamin D, Parathormone (PTH) and type I collagen C-terminal telopeptides in human serum and plasma (CTX).
This new ELISA range will enable you to obtain a full phosphocalcium balance. In addition, it is compatible with our CARIS™ systems.
The new 25-OH D assay reference
- The OCTEIA 25-Hydroxy Vitamin D kit is an immunoenzyme technique intended to assay 25-Hydroxy vitamin D (25-OH D) and other hydroxylated metabolites present in human serum or plasma.
Measuring the serum 25-OH D concentration is considered to be the most reliable method in order to measure the vitamin D level and can therefore be used to determine whether a patient is suffering from vitamin D2 deficiency or not. Evaluation of the vitamin D level may be required to determine the cause of an abnormal serum calcium concentration in patients.
The strengths of our kit are:
• easy-to-use ELISA format, facilitating automation.
• excellent sensitivity (Vitamin D2 + D3 assay).
• quicker than the RIA method. Only 4 hours.
• no radioactivity.
Parathormone (PTH)
- Parathormone (PTH) is a polypeptide hormone containing 84 amino acids (MW 9800 Daltons) secreted by the parathyroid glands; its primary role consists of regulating the ionised calcium level in serum. PTH synthesis and release are determined by the negative retroaction of ionised calcium in parathyroid tissue. Reducing the serum calcium stimulates the release of PTH, which then acts on the kidneys; this encourages the tubular uptake of calcium and stimulates the production of 1,25-dihydroxyvitamin D (which, in turn, amplifies calcium uptake in the intestine) and in bone tissues, thus stimulating osteoclasts and encouraging bone absorption.
Measuring the intact circulatory PTH is particularly important for the differential diagnosis of hypercalcaemia, which enables better differentiation, from a clinical point of view, of patients with hyperparathyroidism and those with malignant hypercalcaemia (MH).
A unique offering providing you with:
• a complementary parameter to Vitamin D.
• easy use due to the ELISA format.
• a fully automatable kit.
CTX, a new complementary parameter to Vitamin D (D2+D3)
- The Serum CrossLaps® ELISA kit is a kit for the immunoenzyme assay of a specific C-terminal sequence for type I collagen in human serum and plasma. The Serum CrossLaps® ELISA kit was developed for in vitro diagnostic use; it indicates the degree of uptake of human bones and can particularly be used in the following contexts:
Detection of changes in bone absorption in cases of:
1. Anti-absorption therapy in menopausal women.
2. Hormone therapy with hormone or hormone analogue.
3. Biphosphonate therapies.
Prediction or response in terms of bone mass in post-menopausal women and following anti-absorption therapy:
1. Hormone therapy with hormone or hormone analogue.
2. Biphosphonate therapies.
Type I collagen accounts for over 90% of organic bone matrix and is essentially synthesised by bone. During skeletal renewal, this type I collagen is broken down and small peptide fragments from the bone are detected in the blood. These fragments can be assayed using the Serum CrossLaps® ELISA kit. The use of this kit has been described in the follow-up of anti-absorption treatments for patients with metabolic bone disorders.
